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Patients with premenstrual syndrome have reduced sensitivity to midazolam compared to control subjects.

Abstract
Premenstrual syndrome (PMS) depends on gonadal hormones produced by the corpus luteum. Given the facilitory actions on GABAergic inhibitory neurotransmission exerted by certain progesterone metabolites, further studies on the GABAA receptor system in premenstrual syndrome are warranted. This study evaluated the benzodiazepine sensitivity in PMS patients and control subjects, using saccadic eye velocity (SEV) and visual analogue ratings of sedation as dependent measures. PMS patients displayed a significantly reduced SEV responsiveness to benzodiazepines compared to control subjects in the follicular phase, whereas there was no difference between groups in the luteal phase. In the luteal phase, the sedation response to benzodiazepines was significantly reduced in PMS patients compared to control subjects. There was also an influence of PMS symptom severity on these measures, as high-severity PMS patients displayed blunted SEV and sedation responses to benzodiazepines compared to low-severity patients. These results indicate that PMS patients have a reduced functional sensitivity at the GABAA/benzodiazepine receptor complex throughout the menstrual cycle.
AuthorsI Sundström, S Nyberg, T Bäckström
JournalNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Neuropsychopharmacology) Vol. 17 Issue 6 Pg. 370-81 (Dec 1997) ISSN: 0893-133X [Print] England
PMID9397425 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Anxiety Agents
  • Progesterone
  • Estradiol
  • Midazolam
Topics
  • Adult
  • Anti-Anxiety Agents (pharmacology)
  • Estradiol (blood)
  • Female
  • Humans
  • Menstrual Cycle (blood, psychology)
  • Midazolam (pharmacology)
  • Middle Aged
  • Pilot Projects
  • Premenstrual Syndrome (blood, psychology)
  • Progesterone (blood)
  • Saccades (drug effects)

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