Methyl-p-hydroxyphenyllactate-esterase activity in breast cancer: a potentially new prognostic factor in short-term follow-up.

Abstract	We assayed methyl-p-hydroxyphenyllactate esterase (MeHPLAase) activity in 48 cases of primary breast cancer. MeHPLAase activity did not show significant correlation with estrogen receptor and progesterone receptor levels. No significant relationship was found between enzymatic activity and tumor diameter, lymph node status, mitotic activity, degree of nuclear differentiation, and proportion of the S-phase fraction. During the follow-up period (median, 18.8 months; range, 6-69 months), recurrences were observed in 18 of 48 (37%) cases. The Weibull survival regression model using the enzymatic activity as a continuous covariate showed that levels of enzymatic activity were directly associated with the risk of recurrence (P = 0.02). Assuming the mean value of enzymatic activity as the cutoff value, we found a statistically significant relationship between high MeHPLAase activity and shorter recurrence-free survival. On multivariate analysis, MeHPLAase activity proved to be an independent factor for predicting a short period of recurrence-free survival.
Authors	A Carbone, F G Serra, G Ferrandina, G Scambia, D Terribile, R Bellantone, M Piantelli, F O Ranelletti
Journal	Cancer research (Cancer Res) Vol. 57 Issue 23 Pg. 5406-9 (Dec 01 1997) ISSN: 0008-5472 [Print] United States
PMID	9393767 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Biomarkers, Tumor Receptors, Estrogen Receptors, Progesterone Carboxylic Ester Hydrolases methyl-p-hydroxyphenyllactate esterase
Topics	Adult Aged Aged, 80 and over Analysis of Variance Biomarkers, Tumor (analysis) Breast Neoplasms (enzymology, mortality, pathology, surgery) Carboxylic Ester Hydrolases (analysis, metabolism) Female Follow-Up Studies Humans Lymph Node Excision Lymphatic Metastasis Middle Aged Mitotic Index Multivariate Analysis Neoplasm Metastasis Neoplasm Recurrence, Local Postmenopause Premenopause Prognosis Receptors, Estrogen (analysis) Receptors, Progesterone (analysis) Regression Analysis Survival Rate Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!