Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP.

Abstract

Upon infection of human cells, the herpes simplex virus protein VP16 associates with the endogenous cell-proliferation factor HCF. VP16 can also associate with HCFs from invertebrates, suggesting that VP16 mimics a cellular protein whose interaction with HCF has been conserved. Here, we show that VP16 mimics the human basic leucine-zipper protein LZIP, which, through association with HCF, may control cell-cycle progression. VP16 and LZIP share a tetrapeptide motif-D/EHXY-used to associate with human HCF. The LZIP-related Drosophila protein BBF-2/dCREB-A contains this HCF-binding motif, indicating that the LZIP-HCF interaction has been conserved during metazoan evolution.

• Authors: R N Freiman, W Herr
• Journal: Genes & development (Genes Dev) Vol. 11 Issue 23 Pg. 3122-7 (Dec 01 1997) ISSN: 0890-9369 [Print] United States
• PMID: 9389645 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• CrebA protein, Drosophila
• Cyclic AMP Response Element-Binding Protein A
• DNA-Binding Proteins
• Drosophila Proteins
• HCFC1 protein, human
• Hcfc1 protein, mouse
• Herpes Simplex Virus Protein Vmw65
• Host Cell Factor C1
• Proteins
• Recombinant Fusion Proteins
• Transcription Factors

Topics

• Amino Acid Sequence
• Animals
• Binding Sites
• Cell Division
• Cell Line, Transformed
• Cyclic AMP Response Element-Binding Protein A
• DNA-Binding Proteins (metabolism)
• Drosophila Proteins
• Drosophila melanogaster
• HeLa Cells
• Herpes Simplex Virus Protein Vmw65 (metabolism)
• Herpesvirus 1, Human (metabolism)
• Host Cell Factor C1
• Humans
• Leucine Zippers
• Mice
• Molecular Mimicry
• Molecular Sequence Data
• Proteins (genetics, metabolism)
• Recombinant Fusion Proteins (genetics, metabolism)
• Sequence Homology, Amino Acid
• Transcription Factors