Abstract | OBJECTIVE: METHOD: A randomized, placebo-controlled trial in 95 children stratified by age and sex was conducted in two hospitals during 1992. AC-17 (n = 45 cases) or B vitamins as placebo (n = 50) were given as a bolus infusion and then as a continuous drip for 24 hours; a total of 300 mg of AC-17 was administered on the first 2 days and 150 mg on the third day. RESULTS: The two groups were comparable in age, sex, duration of illness, and clinical manifestations. No significant difference in shock or pleural effusion was noted between the two groups. Shock developed in 8.9% (4/45) of patients in the AC-17 group and 6% (3/50) in the placebo group (p = 0.44). Pleural effusion was found at 0, 24, 48, and 72 hours after admission in 4.4%, 20%, 31.1%, and 20% in the AC-17 group and 2%, 14%, 28%, and 14% in the placebo group, respectively. CONCLUSION:
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Authors | S Tassniyom, S Vasanawathana, T Dhiensiri, A Nisalak, A Chirawatkul |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 131
Issue 4
Pg. 525-8
(Oct 1997)
ISSN: 0022-3476 [Print] United States |
PMID | 9386652
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hemostatics
- Adrenochrome
- carbazochrome
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Topics |
- Adrenochrome
(analogs & derivatives, pharmacology, therapeutic use)
- Capillary Permeability
(drug effects)
- Child
- Child, Preschool
- Female
- Hemostatics
(pharmacology, therapeutic use)
- Hospitalization
- Humans
- Infant
- Infant, Newborn
- Length of Stay
- Male
- Severe Dengue
(diagnosis, drug therapy, rehabilitation)
- Treatment Failure
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