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Effect of post-operative thyroid hormone therapy on the recurrence of benign thyroid nodules. A study in Thai patients.

Abstract
The efficacy of postoperative thyroid hormone treatment in prevention of recurrent thyroid nodule is still controversial. In order to investigate this effect in Thai patients, a retrospective study was performed on files of 321 post-operative patients with benign thyroid nodules, who were either on thyroid hormone treatment or not after surgery, and were followed-up for at least 1 year. The longest follow-up period was 15 years after surgery. The recurrence of nodules was determined by palpation. It was found that the recurrent rate in patients with adenoma who did not receive post-operative thyroid hormone treatment was 20 per cent (16/82 cases) while there was no recurrence at all (0/25 cases) in the treatment group (p < 0.05). The recurrent rate was 22 per cent (31/141 cases) in patients with nodular goitre who did not receive post-operative thyroid hormone treatment and 7 per cent (5/73 cases) in those with treatment (p < 0.001). In the group of patients without post-operative thyroid hormone treatment, for both the group of patients with adenoma and that with nodular goitres, the recurrence was found to occur as late as more than 10 years after surgery.
AuthorsC Banchuin, S Panpimarnmas
JournalJournal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 80 Issue 11 Pg. 715-9 (Nov 1997) ISSN: 0125-2208 [Print] Thailand
PMID9385768 (Publication Type: Journal Article)
Chemical References
  • Thyroid Hormones
Topics
  • Adenoma (therapy)
  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Cystadenoma (therapy)
  • Female
  • Follow-Up Studies
  • Goiter, Nodular (therapy)
  • Humans
  • Male
  • Middle Aged
  • Postoperative Care
  • Recurrence
  • Retrospective Studies
  • Thailand
  • Thyroid Hormones (administration & dosage)
  • Thyroid Neoplasms (therapy)
  • Thyroidectomy

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