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Release of 5-hydroxytryptamine by hypoxia from epithelioid cells of chicken thoracic aorta.

Abstract
Epithelioid cells in the chicken thoracic aorta are shown to contain 5-hydroxytryptamine (5-HT) in immunocytochemical studies. To determine whether these cells act as chemoreceptors, as do type I cells of the carotid body, we examined the effects of hypoxia and acidosis on the release of 5-HT from the chicken thoracic aorta. Hypoxia caused the output of 5-HT in incubation medium. A reduction of pH to 6.8 failed to evoke 5-HT release. The response to hypoxia was inhibited by the removal of extracellular Ca2+ and by nifedipine and omega-conotoxin GVIA. These results suggest that epithelioid cells in the chicken thoracic aorta are chemoreceptors which sense a decrease in PO2 and then release 5-HT by Ca2+ influx through voltage-dependent L- and N-type Ca2+ channels. The epithelioid cells in the chicken aorta may be a useful model for pharmacological and physiological studies of 5-HT-containing cells.
AuthorsS Ito, T Ohta, Y Nakazato
JournalBritish journal of pharmacology (Br J Pharmacol) Vol. 122 Issue 5 Pg. 799-801 (Nov 1997) ISSN: 0007-1188 [Print] England
PMID9384492 (Publication Type: Journal Article)
Chemical References
  • Calcium Channel Blockers
  • Peptides
  • Serotonin
  • omega-Conotoxin GVIA
  • Nifedipine
  • Calcium
Topics
  • Animals
  • Aorta, Thoracic (cytology, drug effects)
  • Calcium (metabolism)
  • Calcium Channel Blockers (pharmacology)
  • Cell Hypoxia
  • Chemoreceptor Cells (drug effects, metabolism)
  • Chickens
  • Chromatography, High Pressure Liquid
  • Epithelioid Cells (drug effects, metabolism)
  • Hydrogen-Ion Concentration
  • In Vitro Techniques
  • Male
  • Nifedipine (pharmacology)
  • Peptides (pharmacology)
  • Serotonin (metabolism)
  • omega-Conotoxin GVIA

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