Salmonella infection increases porcine antibacterial peptide concentrations in serum.

Abstract

PR-39 is a multifunctional neutrophil peptide involved in host defense and inflammation. To investigate the involvement of PR-39 in a Salmonella choleraesuis infection, a PR-39 enzyme immunoassay was developed. The concentrations of PR-39 in serum were 13.6 +/- 1.9 ng/ml before challenge and increased (P < 0.01) threefold by 10 to 14 days postinfection. Peripheral blood neutrophil counts paralleled the changes in the concentrations of PR-39 in serum, both returned to basal values by 4 weeks postinfection. These findings suggest that the concentrations of serum PR-39 reflect the involvement of this antibacterial peptide in the host's response to an S. choleraesuis infection.

• Authors: G Zhang, C R Ross, S S Dritz, J C Nietfeld, F Blecha
• Journal: Clinical and diagnostic laboratory immunology (Clin Diagn Lab Immunol) Vol. 4 Issue 6 Pg. 774-7 (Nov 1997) ISSN: 1071-412X [Print] United States
• PMID: 9384306 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Anti-Bacterial Agents
• Antimicrobial Cationic Peptides
• Peptides
• PR 39
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Anti-Bacterial Agents (blood)
• Antimicrobial Cationic Peptides
• Blood Bactericidal Activity
• Enzyme-Linked Immunosorbent Assay
• Goats
• Mice
• Mice, Inbred BALB C
• Neutrophil Activation (drug effects, physiology)
• Neutrophils (drug effects, metabolism)
• Peptides (blood)
• Salmonella Infections, Animal (blood, immunology)
• Stimulation, Chemical
• Swine
• Tetradecanoylphorbol Acetate (pharmacology)