HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Photoinactivation of virus infectivity by hypocrellin A.

Abstract
We investigated the photoinactivation of virus infectivity by hypocrellin A and its mechanism. The titers of vesicular stomatitis virus (VSV) and human immunodeficiency virus type 1 (HIV-1), both of which are enveloped viruses, were reduced upon illumination with hypocrellin A in a concentration-dependent manner, whereas canine parvovirus, a nonenveloped virus, was not killed. The removal of oxygen or addition of sodium azide or beta-carotene both inhibited VSV inactivation. Mannitol and superoxide dismutase had no effect on VSV inactivation. These results indicate that singlet oxygen was involved in the process of VSV inactivation. Of the three major VSV membrane proteins, peripheral membrane protein M was most damaged by the hypocrellin A phototreatment.
AuthorsJ Hirayama, K Ikebuchi, H Abe, K W Kwon, Y Ohnishi, M Horiuchi, M Shinagawa, K Ikuta, N Kamo, S Sekiguchi
JournalPhotochemistry and photobiology (Photochem Photobiol) Vol. 66 Issue 5 Pg. 697-700 (Nov 1997) ISSN: 0031-8655 [Print] United States
PMID9383993 (Publication Type: Journal Article)
Chemical References
  • Antiviral Agents
  • Photosensitizing Agents
  • Quinones
  • Viral Proteins
  • Singlet Oxygen
  • Phenol
  • Perylene
  • Oxygen
  • hypocrellin A
Topics
  • Animals
  • Antiviral Agents (pharmacology)
  • Cell Line
  • Dogs
  • HIV-1 (drug effects, radiation effects)
  • Humans
  • Oxygen (metabolism)
  • Parvovirus, Canine (drug effects, radiation effects)
  • Perylene (analogs & derivatives, pharmacology)
  • Phenol
  • Photochemotherapy
  • Photosensitizing Agents (pharmacology)
  • Quinones (pharmacology)
  • Singlet Oxygen
  • Vesicular stomatitis Indiana virus (drug effects, radiation effects)
  • Viral Proteins (drug effects, radiation effects)
  • Virulence (drug effects, radiation effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: