[Muscular complications in HIV infection].

Abstract

Skeletal muscle involvement may occur at all stages of HIV-infection and represents the first manifestation of the disease into some patients. We usually classify muscle involvement in HIV-infected patients in one of the following categories: HIV-associated myopathy, a myopathy that meets the criteria for polymyositis in a majority of patients, and those for acquired nemaline myopathy in some cases (1); zidovudine myopathy, a reversible mitochondrial myopathy (2); HIV-wasting syndrome and other AIDS-associated cachexias (3); opportunistic infections and tumor infiltrations of the skeletal muscle (4); vasculitic processes and iron pigment deposits (5); HIV-associated myasthenia gravis (6) and rhabdomyolysis (7). Immunohistology for major histocompatibility complex class I antigen and histochemical reaction for cytochrome coxidase are helpful in the correct classification of a myopathy as HIV polymyositis or zidovudine myopathy.

• Authors: F J Authier, P Chariot, R Gherardi
• Journal: Archives d'anatomie et de cytologie pathologiques (Arch Anat Cytol Pathol) Vol. 45 Issue 2-3 Pg. 174-8 ( 1997) ISSN: 0395-501X [Print] France
• Vernacular Title: Complications musculaires de l'infection par le VIH.
• PMID: 9382610 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anti-HIV Agents
• Zidovudine

Topics

• AIDS-Related Opportunistic Infections (complications)
• Anti-HIV Agents (adverse effects, therapeutic use)
• HIV Infections (complications, drug therapy)
• Humans
• Muscular Diseases (chemically induced, classification, etiology, virology)
• Zidovudine (adverse effects, therapeutic use)