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[Visualising lymph nodes by aclarubicin bound to activated carbon particles in breast cancer surgery].

Abstract
A new dosage formulation (ACR-CH), composed of aclarubicin (ACR) bound to fine activated carbon particles, has been developed for the treatment of lymph node metastases in breast cancer. ACR-CH is designed to (a) adsorb a great amount of aclarubicin and desorb in a free state; (b) distribute a greater amount of ACR for a longer period of time selectively to the regional lymph nodes; (c) be decreased in the systemic toxicity; and (d) enhance its therapeutic effect on lymph node metastases. In this clinical trial in 20 patients with breast cancer, ACR-CH was injected intra- and peritumorally just before operation for breast cancer, and we examined the extent of blackened nodes produced by ACR-CH. ACR-CH blackened about 70% of the axillary lymph nodes with cancer metastasis as well as the nodes without metastasis. In conclusion, ACR-CH will be useful for dissection of lymph nodes by visualizing the nodes during operation for breast cancer.
AuthorsT Imanishi, A Hagiwara, K Sawai, T Yamaguchi, C Sakakura, M Shirasu, M Ohgaki, J Yamasaki, T Togawa, T Takahashi
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 24 Issue 12 Pg. 1796-8 (Sep 1997) ISSN: 0385-0684 [Print] Japan
PMID9382535 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Dosage Forms
  • Carbon
  • Aclarubicin
Topics
  • Aclarubicin (administration & dosage, pharmacokinetics)
  • Animals
  • Antibiotics, Antineoplastic (administration & dosage, pharmacokinetics)
  • Breast Neoplasms (pathology, surgery)
  • Carbon (pharmacokinetics)
  • Dosage Forms
  • Female
  • Humans
  • Lymph Node Excision
  • Lymph Nodes (pathology)
  • Lymphatic Metastasis (pathology)
  • Rats

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