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[A case of multiple colonic liver metastases treated successfully with percutaneous isolated liver chemoperfusion using cisplatin]

AbstractWe herein report a case of multiple colonic liver metastases treated with repeated percutaneous isolated liver chemoperfusion of cisplatin under hepatic venous isolation and charcoal hemoperfusion (HVI.CHP) as an inductive treatment. The patient was a 70-year-old man who underwent curative resections for metachronous rectal and descending colonic cancer in 1979 and 1995, respectively. During outpatient follow-up, he showed increases of serum CEA level. An abdominal CT study demonstrated multiple low-density lesions in the bilateral lobes of the liver, indicating colonic liver metastases. The patient had a total of 2 treatments with percutaneous isolated liver chemoperfusion of cisplatin (total dose, 500 mg) under HVI.CHP. His post-treatment course was uneventful without side effects, including leukopenia and renal dysfunction. Serum CEA levels showed a sharp decrease to 160 ng/ml 3 months after treatment from the pretreatment value of 1,064 ng/ml. CT scan 3 months after treatment revealed remarkable tumor regression along with liquefaction of liver tumors, showing a partial response. These results suggested that repeated percutaneous isolated liver chemoperfusion of cisplatin under HVI.CHP is a potent inductive treatment for patients with multiple colonic liver metastases.
AuthorsT Sugimoto, Y Ku, M Tominaga, T Iwasaki, S Muramatsu, N Kusunoki, Y Kuroda (Affiliation: First Dept. of Surgery, Kobe University School of Medicine.)
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 24 Issue 12 Pg. 1753-6 (Sep 1997) ISSN: 0385-0684 JAPAN
PMID9382524 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Cisplatin
Topics
  • Aged
  • Antineoplastic Agents (administration & dosage)
  • Chemotherapy, Cancer, Regional Perfusion
  • Cisplatin (administration & dosage)
  • Colonic Neoplasms (pathology)
  • Hemoperfusion
  • Hepatic Artery
  • Humans
  • Infusions, Intra-Arterial
  • Liver Neoplasms (drug therapy, secondary)
  • Male