[A case of advanced hepatocellular carcinoma with portal invasion effectively treated by continuous intra-arterial chemotherapy with 5-fluorouracil].

Abstract

A 79-year-old male diagnosed as advanced hepatocellular carcinoma with portal invasion was treated by continuous intra-arterial chemotherapy of 5-FU, which was continuously administered for 72 hours at a dose of 333 mg/mm/day every 2 weeks and repeated 12 times. Total dose of 5-FU was 14.4 g. Toxicity of this therapy was not recognized. Levels of AFP were reduced from 4385.6 ng/ml to 11.9 for 6 months. No tumor was recognized on CT scan at 6 months after starting this therapy, after 15 months of this therapy, the patient is alive and disease-free. Given the above results, continuous intra-arterial administration of this 5-FU therapy may be effective for patients with hepatocellular carcinoma.

• Authors: A Sawamura, R Kim, I Takashima, E Miyahara, K Aogi, Y Yamaguchi, K Noma, J Hihara, T Toge
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 24 Issue 12 Pg. 1738-40 (Sep 1997) ISSN: 0385-0684 [Print] Japan
• PMID: 9382520 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Fluorouracil

Topics

• Aged
• Antimetabolites, Antineoplastic (administration & dosage)
• Carcinoma, Hepatocellular (drug therapy, pathology)
• Fluorouracil (administration & dosage)
• Humans
• Infusions, Intra-Arterial (methods)
• Liver Neoplasms (drug therapy, pathology)
• Male
• Neoplasm Invasiveness
• Portal System (pathology)
• Vascular Neoplasms (pathology)