HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Medetomidine protection against diazinon-induced toxicosis in mice.

Abstract
The protective effect of the alpha2-agonist medetomidine against the organophosphorus insecticide diazinon-induced toxicosis was examined in male mice. Oral dosing of diazinon at 75 and 100 mg/kg produced signs of toxicosis in mice characteristic of cholinergic over-stimulation, and the percentages of deaths were 90 and 100%, respectively. Subcutaneous (s.c.) injection of medetomidine at 0.05, 0.1 and 0.3 mg/kg, 15 min before diazinon (75 mg/kg, orally) significantly and dose-dependently decreased the incidence of toxic manifestations, delayed the onset of tremors and death, and increased the 24 h survival rates to 70, 80 and 100%, respectively. Similarly medetomidine pretreatments (0.1 and 0.3 mg/kg, s.c) significantly protected the mice from the toxicity of a high dose (100 mg/kg, orally) of diazinon, and increased the 24 h survival rates to 38 and 50%, respectively. The alpha2-antagonist atipamezole significantly abolished the protective effect of medetomidine. When atropine sulfate (6 mg/kg, s.c.) was combined with medetomidine (0.3 mg/kg, s.c.) the degree of protection against diazinon toxicosis was more than that produced by either drug alone. The data suggest that medetomidine protected mice against diazinon-induced toxicosis, and a combination of medetomidine and atropine produced an even greater degree of protection.
AuthorsL K Yakoub, F K Mohammad
JournalToxicology letters (Toxicol Lett) Vol. 93 Issue 1 Pg. 1-8 (Sep 19 1997) ISSN: 0378-4274 [Print] Netherlands
PMID9381477 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adrenergic alpha-Agonists
  • Adrenergic alpha-Antagonists
  • Cholinesterase Inhibitors
  • Cholinesterase Reactivators
  • Imidazoles
  • Insecticides
  • Parasympatholytics
  • atipamezole
  • Atropine
  • Medetomidine
  • Diazinon
Topics
  • Adrenergic alpha-Agonists (pharmacology)
  • Adrenergic alpha-Antagonists (pharmacology)
  • Animals
  • Atropine (pharmacology)
  • Cholinesterase Inhibitors (toxicity)
  • Cholinesterase Reactivators
  • Diazinon (antagonists & inhibitors, toxicity)
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Drug Therapy, Combination
  • Imidazoles (pharmacology)
  • Insecticides (antagonists & inhibitors, toxicity)
  • Lethal Dose 50
  • Male
  • Medetomidine
  • Mice
  • Nervous System Diseases (chemically induced, prevention & control)
  • Parasympatholytics (pharmacology)
  • Survival Rate

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: