Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia.
| Authors | M D Meyer, R J Altenbach, F Z Basha, W A Carroll, I Drizin, S W Elmore, P P Ehrlich, S A Lebold, K Tietje, K B Sippy, M D Wendt, D J Plata, F Plagge, S A Buckner, M E Brune, A A Hancock, J F Kerwin Jr |
| Journal | Journal of medicinal chemistry
(J Med Chem)
Vol. 40
Issue 20
Pg. 3141-3
(Sep 26 1997)
ISSN: 0022-2623 [Print] United States |
| PMID | 9379432
(Publication Type: Comparative Study, Journal Article)
|
| Chemical References |
- A 131701
- ADRA1A protein, human
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-Antagonists
- Indoles
- Isoindoles
- Pyrimidinones
- Receptors, Adrenergic, alpha-1
- Sulfonamides
- Terazosin
- Tamsulosin
- Prazosin
|
| Topics |
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-Antagonists
(chemical synthesis, therapeutic use)
- Animals
- Dogs
- Humans
- Indoles
(chemical synthesis, therapeutic use)
- Isoindoles
- Male
- Models, Chemical
- Prazosin
(analogs & derivatives, therapeutic use)
- Prostatic Hyperplasia
(drug therapy)
- Pyrimidinones
(chemical synthesis, therapeutic use)
- Rats
- Receptors, Adrenergic, alpha-1
- Sulfonamides
(therapeutic use)
- Tamsulosin
|
|
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