Abstract | UNLABELLED: 18 patients with refractory complex partial seizures with or without secondary generalization resistant at common AED were studied. They were treated in a open label study with felbamate for a 22 months period. Felbamate monotherapy show a statistical significant improvement in the control of seizures in these patients versus CBZ therapy. No severe side effects were reported specially aplastic anemia or hepatic failure. At present, after 2 years, all the patients are still treated with felbamate. CONCLUSIONS:
felbamate appears to be an effective new AED: the most adverse effects occurring during administration of FBM are mild to moderate gastrointestinal ( nausea, vomiting and anorexia) and central nervous system ( headache, sonnolence, diplopia, dizziness and insomnia) disturbances. These adverse effects last, generally, for three weeks and allow to continue the treatment.
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Authors | F De Romanis, N Sopranzi |
Journal | La Clinica terapeutica
(Clin Ter)
Vol. 148
Issue 3
Pg. 83-7
(Mar 1997)
ISSN: 0009-9074 [Print] Italy |
Vernacular Title | Felbamato: uno studio protratto nel tempo in soggetti con epilessia resistente. |
PMID | 9377844
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anticonvulsants
- Phenylcarbamates
- Propylene Glycols
- Felbamate
|
Topics |
- Adolescent
- Adult
- Anticonvulsants
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Epilepsies, Partial
(drug therapy)
- Epilepsy
(drug therapy)
- Felbamate
- Female
- Humans
- Male
- Middle Aged
- Phenylcarbamates
- Propylene Glycols
(administration & dosage, therapeutic use)
- Seizures
(drug therapy)
- Treatment Outcome
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