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The maintenance of per-operative mydriasis in phacoemulsification with topical diclofenac sodium.

AbstractPURPOSE:
To determine whether the use of topical diclofenac sodium (diclofenac) pre-operatively improves the maintenance of per-operative mydriasis, in conjunction with irrigating solutions containing adrenaline.
METHODS:
Sixty-four consecutive patients undergoing phacoemulsification were randomised to receive either diclofenac or no diclofenac in conjunction with cyclopentolate 1% and phenylephrine 10% pre-operatively. They subsequently underwent routine phacoemulsification by one consultant surgeon. Irrigating solutions of balanced salt solution contained adrenaline 1:10(6). Pupil diameters were measured pre-sclerostomy, post-phacoemulsification, post-irrigation/aspiration and on day 1 post-operatively. These were then compared by Student's t-test.
RESULTS:
The two groups were statistically similar in age and sex. The mean pre-sclerostomy pupillary diameters were 8.1 mm in both groups. The mean post-phacoemulsification diameters were 7.6 mm in those receiving diclofenac and 7.2 mm in those not (p = 0.03). The mean diameters after infusion/aspiration were 7.7 mm in those receiving diclofenac and 7.1 mm in those not (p = 0.008). The mean pupillary diameters on day 1 were 5.3 mm in those receiving diclofenac and 4.6 mm in those not (p = 0.003).
CONCLUSION:
Diclofenac improves the maintenance of per-operative mydriasis, in the presence of irrigating solutions containing adrenaline.
AuthorsR J Antcliff, D R Trew
JournalEye (London, England) (Eye (Lond)) Vol. 11 ( Pt 3) Pg. 389-91 ( 1997) ISSN: 0950-222X [Print] England
PMID9373483 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Cyclooxygenase Inhibitors
  • Mydriatics
  • Diclofenac
  • Phenylephrine
  • Cyclopentolate
  • Epinephrine
Topics
  • Aged
  • Aged, 80 and over
  • Cyclooxygenase Inhibitors (pharmacology)
  • Cyclopentolate (pharmacology)
  • Diclofenac (pharmacology)
  • Epinephrine (pharmacology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mydriatics (pharmacology)
  • Phacoemulsification
  • Phenylephrine (pharmacology)
  • Preanesthetic Medication
  • Prospective Studies
  • Pupil (drug effects)

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