HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution.

Abstract
Chromosomal translocations involving band 5q31-35 occur in several hematologic disorders. A clone with a t(5; 14)(q33; q32) translocation appeared at the relapse phase in a patient with acute myelogenous leukemia who exhibited a sole chromosomal translocation, t(7; 11), at initial diagnosis. After the appearance of this clone, the leukemia progressed with marked eosinophilia, and combination chemotherapy was ineffective. Southern blot analysis showed a rearrangement of the platelet-derived growth factor receptor beta (PDGFRbeta) gene at 5q33 which was not observed at initial diagnosis. This translocation resulted in a chimeric transcript fusing the PDGFRbeta gene on 5q33 with a novel gene, CEV14, located at 14q32. Expression of the 5' region of the PDGFRbeta cDNA, upstream of the breakpoint, was not detected. However, the 3' region of PDGFRbeta, which was transcribed as part of the CEV14-PDGFRbeta fusion gene, was detected. A partial cDNA for a novel gene, CEV14, includes a leucine zipper motif and putative thyroid hormone receptor interacting domain and is expressed in a wide range of tissues. The expression of a CEV14-PDGFRbeta fusion gene in association with aggressive leukemia progression suggests that this protein has oncogenic potential.
AuthorsA Abe, N Emi, M Tanimoto, H Terasaki, T Marunouchi, H Saito
JournalBlood (Blood) Vol. 90 Issue 11 Pg. 4271-7 (Dec 01 1997) ISSN: 0006-4971 [Print] United States
PMID9373237 (Publication Type: Journal Article)
Chemical References
  • CEV14-PDGFRbeta fusion protein, human
  • Cytoskeletal Proteins
  • Nuclear Proteins
  • Oncogene Proteins, Fusion
  • Platelet-Derived Growth Factor
  • Proteins
  • TRIP11 protein, human
  • Receptor, Platelet-Derived Growth Factor beta
  • Receptors, Platelet-Derived Growth Factor
Topics
  • Amino Acid Sequence
  • Base Sequence
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 5
  • Clone Cells (chemistry)
  • Cytoskeletal Proteins
  • Eosinophilia (genetics, pathology)
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Myeloid, Acute (genetics, pathology)
  • Molecular Sequence Data
  • Nuclear Proteins
  • Oncogene Proteins, Fusion (chemistry, genetics)
  • Platelet-Derived Growth Factor
  • Polymerase Chain Reaction
  • Proteins (chemistry, genetics)
  • Receptor, Platelet-Derived Growth Factor beta
  • Receptors, Platelet-Derived Growth Factor (genetics)
  • Translocation, Genetic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: