| Abstract | In order to clarify the pathogenesis of hypercalcemia in multiple myeloma, we measured plasma levels of parathyroid hormone related peptide (PTHrP), tumor necrosis factor alpha (TNF-alpha), tumor necrosis factor beta (TNF-beta), intact PTH and, serum 1,25-dihydroxyvitamin D in fifteen patients of multiple myeloma. We also measured serum levels of inorganic phosphorus (iP) and alkalinephosphatase activity (ALP). No significant differences in iP (3.2 +/- 0.4 vs. 4.0 +/- 2.2 mg/dl), ALP (150 +/- 28 vs. 335 +/- 305 IU/l) 1,25(OH)2 D (31.5 +/- 17.0 vs. 23.3 +/- 11.2 pg/ml) or TNF-alpha (7.8 +/- 2.1 vs. 8.0 +/- 2.0 pg/ml) were observed between normocalcemic and hypercalcemic patients. Plasma iPTH levels in hypercalcemic patients were significantly lower than those in normocalcemic patients (28.5 +/- 9.4 vs. 16.3 +/- 5.6 pg/ml, p = 0.01). Plasma levels of TNF-beta were less than 15.6 pg/ml in all subjects. On the other hand, the frequency of patients with abnormally high plasma levels of PTHrP was significantly greater (2/9 for normocalcemia vs 5/6 for hypercalcemia, chi 2 = 5.20, p = 0.02) in patients with hypercalcemia than in normocalcemic patients. Furthermore, a significant positive relationship between plasma PTHrP levels and corrected serum calcium levels (cCa) was observed using Spearman's correlation analysis by rank in fifteen myeloma cases (rs = 0.66, p = 0.013). These results suggest that PTHrP might be involved in the elevation of serum calcium levels in hypercalcemic myeloma patients. However, a few cases exhibit normocalcemia despite elevated plasma PTHrP levels or hypercalcemia without high plasma PTHrP levels. Therefore, further studies are necessary to elucidate the pathogenesis of hypercalcemia in multiple myeloma. |
| Authors | T Horiuchi, T Miyachi, T Arai, T Nakamura, M Mori, H Ito
(Affiliation: Section of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Japan.)
|
| Journal | Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et métabolisme
(Horm Metab Res)
Vol. 29
Issue 9
Pg. 469-71
(Sep 1997)
ISSN: 0018-5043 GERMANY |
| PMID | 9370119
(Publication Type: Journal Article)
|
| Chemical References |
- Lymphotoxin-alpha
- PTHLH protein, human
- Parathyroid Hormone
- Parathyroid Hormone-Related Protein
- Proteins
- Tumor Necrosis Factor-alpha
- Calcitriol
- Phosphorus
- Alkaline Phosphatase
|
| Topics |
- Aged
- Alkaline Phosphatase
(blood)
- Calcitriol
(blood)
- Humans
- Hypercalcemia
(blood, complications)
- Lymphotoxin-alpha
(blood)
- Middle Aged
- Multiple Myeloma
(blood, complications)
- Parathyroid Hormone
(blood)
- Parathyroid Hormone-Related Protein
- Phosphorus
(blood)
- Proteins
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
|
