| Abstract | BACKGROUND AND OBJECTIVES: The 1990s have established the contribution of multimodality therapy in the management of IIIb noninflammatory breast cancer (IIIb NIBC), by reducing the odds of recurrence and death. METHODS: A total of 300 women with IIIb NIBC received a multimodality therapy. The treatment consisted of neoadjuvant chemotherapy [FAC (5-fluorouracil, Adriamycin, cyclophosphamide) regimen], radical (Halsted) mastectomy or modified (Patey mastectomy), postoperative radiotherapy, and adjuvant chemohormone therapy [FAC regimen + cyclophosphamide, 5-fluorouracil and methotrexate (CMF) regimen or Tamoxifen]. RESULTS: Complete or partial clinical response (CR or PR) after neoadjuvant chemotherapy was obtained in 83% patients. Ninety-nine patients (33%) survived 5 years without evidence of disease (NED). The uni- and multivariate analyses factors that had significant influence on the treatment results were: clinical response to neoadjuvant chemotherapy, pathological tumor size, and microscopical status of the axillary lymph nodes. CONCLUSIONS: We conclude that neoadjuvant FAC regimen chemotherapy is very effective in producing objective tumor regression and offers the benefit of radical mastectomy to patients with previously unresectable IIIb NIBC. |
| Authors | B Gliński, M Pawlicki, M Reinfuss, J Skołyszewski, A Brandys, K Krzemieniecki, B Zuchowska, J Mitus, A Stelmach, T Walasek
(Affiliation: Department of Radiotherapy, Maria Sklodowska-Curie Memorial Center of Oncology, Cracow, Poland.)
|
| Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 66
Issue 3
Pg. 179-85
(Nov 1997)
ISSN: 0022-4790 UNITED STATES |
| PMID | 9369963
(Publication Type: Clinical Trial, Journal Article)
|
| Chemical References |
- CAF protocol
- CMF regimen
- Tamoxifen
- Doxorubicin
- Cyclophosphamide
- Fluorouracil
- Methotrexate
|
| Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(drug therapy, radiotherapy, surgery, therapy)
- Chemotherapy, Adjuvant
- Combined Modality Therapy
- Cyclophosphamide
(administration & dosage)
- Disease-Free Survival
- Doxorubicin
(administration & dosage)
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Lymph Node Excision
- Mastectomy, Modified Radical
- Mastectomy, Radical
- Methotrexate
(administration & dosage)
- Middle Aged
- Survival Analysis
- Tamoxifen
(administration & dosage)
|
