Cardiovascular effects of elgodipine and nifedipine compared in anaesthetized rats.
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| Abstract |
The cardiovascular effects of elgodipine were studied and compared with those of nifedipine in the presence or absence of ganglion blockade. A bolus of elgodipine (5-25 microg/kg) or nifedipine (60-120 microg/kg) was given and sequential cardiovascular effects in rats were recorded. Both dihydropyridines induced a dose-dependent decrease in mean arterial pressure but, whereas nifedipine induced reflex tachycardia, elgodipine induced a dose-dependent bradycardia. Both substances induced decreases in left ventricular d P/dt(max) without significant changes in central venous pressure. Good linear correlation was observed between the elgodipine-induced decrease in mean arterial pressure and those of heart rate and left ventricular dP/dt(max). The profile of the decrease in mean arterial pressure in animals pretreated with hexametonium chloride (20 mg/kg) was the same but the nifedipine-induced tachycardia was abolished without changes in elgodipine-induced bradycardia. These characteristics of elgodipine makes this dihydropyridine a potentially beneficial therapeutic agent in the case of severe hypertension accompanied by obstructive coronopathy.
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| Authors | J M Valdivielso, J F Macías, J M López-Novoa |
| Journal | European journal of pharmacology (Eur J Pharmacol) Vol. 335 Issue 2-3 Pg. 193-8 (Sep 24 1997) ISSN: 0014-2999 [Print] Netherlands |
| PMID | 9369373 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't) |
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