Antiamnesic activity of metoclopramide, cisapride and SR-17 in the mouse passive avoidance test.

Abstract

The effects of the administration of metoclopramide, cisapride and SR-17 on memory processes were evaluated in the mouse passive avoidance test. The administration of dicyclomine (0.1-3 mg kg-1 i.p.), immediately after termination of the training session, produced a dose-dependent amnesic effect. Metoclopramide (1-5 mg kg-1 i.p.), cisapride (0.5-2 mg kg-1 i.p.) and SR-17 (1-10 mg kg-1 i.p.), administered 20 min before the training session, prevented dicyclomine-induced amnesia. In the same experimental conditions piracetam (30 mg kg-1 i.p.), physostigmine (0.2 mg kg-1 i.p.) and CGP 35348 (100 mg kg-1 i.p.) prevented dicyclomine amnesia. At the highest effective doses, none of the drugs impaired motor coordination, as revealed by the rota-rod test, nor did they modify spontaneous motility, as revealed by the Animex test. These results suggest that metoclopramide, cisapride and SR-17 play an important role in the modulation of memory processes. On these bases, these compounds could be useful in the treatment of cognitive deficits.

• Authors: N Galeotti, C Ghelardini, E Teodori, F Gualtieri, A Bartolini
• Journal: Pharmacological research (Pharmacol Res) Vol. 36 Issue 1 Pg. 59-67 (Jul 1997) ISSN: 1043-6618 [Print] Netherlands
• PMID: 9368916 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzofurans
• Bridged Bicyclo Compounds
• Dopamine Antagonists
• Muscarinic Antagonists
• Piperidines
• Serotonin Antagonists
• Serotonin Receptor Agonists
• endo 8-methyl-8-azabicyclo(3.2.1)octan-3-yl benzofurane-3-carboxylate
• Dicyclomine
• Metoclopramide
• Cisapride

Topics

• Amnesia (chemically induced, prevention & control)
• Animals
• Avoidance Learning (drug effects)
• Behavior, Animal (drug effects)
• Benzofurans (pharmacology)
• Bridged Bicyclo Compounds (pharmacology)
• Cisapride
• Dicyclomine (pharmacology)
• Dopamine Antagonists (pharmacology)
• Dose-Response Relationship, Drug
• Male
• Memory (drug effects)
• Metoclopramide (pharmacology)
• Mice
• Motor Activity (drug effects)
• Muscarinic Antagonists (pharmacology)
• Piperidines (pharmacology)
• Serotonin Antagonists (pharmacology)
• Serotonin Receptor Agonists (pharmacology)