Follicular mucinosis associated with scarring alopecia, oligoclonal T-cell receptor V beta expansion, and Staphylococcus aureus: when does follicular mucinosis become mycosis fungoides?

Abstract

A diagnosis of alopecia mucinosa, occurring as a single scalp lesion, was made in a 40-year-old white woman who had a history of trauma. Follicular mucinosis, Staphylococcus aureus, and oligoclonal expansion of the T-cell receptor V beta chain genes 6 and 7 were present in the skin. Epidermotropic T-cell skin diseases with oligoclonal T-cell proliferations may be the result of HLA- and cytokine-determined reaction patterns to persistent antigens.

• Authors: C M Jackow, E Papadopoulos, B Nelson, J A Tschen, G Heatherington, M Duvic
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 37 Issue 5 Pt 2 Pg. 828-31 (Nov 1997) ISSN: 0190-9622 [Print] United States
• PMID: 9366845 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Receptors, Antigen, T-Cell

Topics

• Adult
• Alopecia (etiology, pathology)
• Biopsy
• Cicatrix (etiology)
• Diagnosis, Differential
• Female
• Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
• Humans
• Mucinosis, Follicular (diagnosis, microbiology)
• Mycosis Fungoides (immunology, pathology)
• Polymerase Chain Reaction
• Precancerous Conditions (immunology, pathology)
• Receptors, Antigen, T-Cell (genetics)
• Scalp (injuries, microbiology, pathology, surgery)
• Skin Neoplasms (immunology, pathology)
• Staphylococcus aureus (isolation & purification)
• T-Lymphocytes (pathology)