Abstract |
A prospective study in 207 children aged 0.5-15 years was carried out to examine the relationship between cellular responses to Plasmodium falciparum ring-infected erythrocyte surface antigen (RESA) and malaria infection and morbidity. The prevalence of lymphoproliferative response to RESA was 13%, IFN-gamma prevalence was 40% and IL-4 prevalence was 22%. Only the IFN-gamma, response to RESA increased significantly with age. When proliferation or stimulation of either cytokine was used to assess T-cell activation the overall frequency of responders increased to 55%. The proliferative and IFN-gamma response to RESA were positively associated. Although there was no association between any of the CMI responses to RESA and concurrent morbidity the prevalence of IL-4 response to RESA was significantly lower in children who experienced clinical malaria in the following year. These results coupled with our earlier data showing a negative relationship between humoral responses to RESA and malaria morbidity support the inclusion of RESA in a subunit vaccine against malaria.
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Authors | F al-Yaman, B Genton, J Taraika, R Anders, M P Alpers |
Journal | Parasite immunology
(Parasite Immunol)
Vol. 19
Issue 6
Pg. 249-54
(Jun 1997)
ISSN: 0141-9838 [Print] England |
PMID | 9364554
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Antigens, Protozoan
- Protozoan Proteins
- Recombinant Fusion Proteins
- ring-infected erythrocyte surface antigen (RESA), Plasmodium falciparum
- Interleukin-4
- Interferon-gamma
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Topics |
- Adolescent
- Animals
- Antigens, Protozoan
(immunology)
- Cell Division
- Cells, Cultured
- Child
- Child, Preschool
- Cohort Studies
- Endemic Diseases
- Humans
- Infant
- Interferon-gamma
(immunology)
- Interleukin-4
(immunology)
- Leukocytes, Mononuclear
(cytology)
- Malaria
(epidemiology, immunology)
- Papua New Guinea
(epidemiology)
- Plasmodium falciparum
(immunology)
- Prospective Studies
- Protozoan Proteins
(immunology)
- Recombinant Fusion Proteins
(immunology)
- T-Lymphocytes
(immunology)
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