Polyenylphosphatidylcholine decreases alcoholic hyperlipemia without affecting the alcohol-induced rise of HDL-cholesterol.

Abstract

In ethanol-fed rats, supplementation of the diet with soybean polyenylphosphatidylcholine (3 g/liter for 21 days) markedly decreased postprandial VLDL-triglycerides and both VLDL- and LDL-cholesterol levels, whereas it maintained high levels of HDL-cholesterol, compared to an equivalent intake of choline and polyunsaturated fatty acids. By contrast, there were no changes in the serum lipoproteins of the pair-fed controls. The prevention of alcoholic hypertriglyceridemia was associated with marked attenuation of the alcoholic fatty liver and it occurred despite a slight increase in fat absorption. Thus, the administration of polyenylphosphatidylcholine not only attenuates the hepatotoxicity of ethanol, but also increases the HDL/LDL cholesterol ratio, which may be beneficial for the prevention of atherosclerosis and coronary heart disease.

• Authors: K P Navder, E Baraona, C S Lieber
• Journal: Life sciences (Life Sci) Vol. 61 Issue 19 Pg. 1907-14 ( 1997) ISSN: 0024-3205 [Print] Netherlands
• PMID: 9364195 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cholesterol, HDL
• Hypolipidemic Agents
• Lipoproteins
• Phosphatidylcholines
• Triglycerides
• lipostabil
• Ethanol

Topics

• Animals
• Cholesterol, HDL (blood)
• Disease Models, Animal
• Ethanol (toxicity)
• Hyperlipidemias (blood, chemically induced, prevention & control)
• Hypolipidemic Agents (therapeutic use)
• Lipoproteins (blood)
• Phosphatidylcholines (therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Triglycerides (blood)