HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparison of indocyanine green and fluorescein angiography of choroidal neovascularization.

Abstract
We compared indocyanine green (ICG) and fluorescein angiography for evaluation of choroidal neovascularization (CNV). Cast preparations of CNV induced in monkey eyes by laser photocoagulation were correlated with ICG and fluorescein angiographies of the same CNV formations. Fluorescein angiography was more effective, in general, than ICG angiography in detecting CNV; however, CNVs with subretinal hemorrhage (2 of 35 sites) were visible only with ICG angiography. In early phase ICG angiography, CNV formations that casts showed to be dense or composed of thick vessels were seen, but less dense areas were not visible. Lesions that ICG angiography revealed as leaking were not differentiated morphologically from non-leaking areas by the CNV casts. This study confirms that only ICG angiography can identify CNV hidden by subretinal hemorrhage, although fluorescein angiography is otherwise superior. Indocyanine green angiography is indicated as a valuable complement to fluorescein angiography for evaluation of CNV.
AuthorsI Fukushima, K Kusaka, K Takahashi, N Kishimoto, T Nishimura, H Ohkuma, M Uyama
JournalJapanese journal of ophthalmology (Jpn J Ophthalmol) 1997 Sep-Oct Vol. 41 Issue 5 Pg. 284-96 ISSN: 0021-5155 [Print] Japan
PMID9363556 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Coloring Agents
  • Indocyanine Green
  • Fluorescein
Topics
  • Animals
  • Choroid (blood supply, pathology)
  • Coloring Agents
  • Corrosion Casting
  • Disease Models, Animal
  • Fluorescein
  • Fluorescein Angiography
  • Image Processing, Computer-Assisted
  • Indocyanine Green
  • Laser Coagulation (adverse effects)
  • Macaca mulatta
  • Microscopy, Electron, Scanning
  • Neovascularization, Pathologic (diagnosis, etiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: