Abstract | BACKGROUND: METHODS: In this double-blind, randomized, prospective study 40 patients with gastric ulcer were treated with nocloprost, a stable prostaglandin E2 derivative, or with ranitidine. All subjects underwent endoscopy before and after 4 and 8 weeks of anti- ulcer therapy. During endoscopy mucosal biopsies were performed for determination of EGF content in gastric mucosa at the ulcer margin and in the intact mucosa. Additionally, EGF output in saliva and its plasma concentrations were determined in all subjects before and during the treatment. RESULTS: The gastric ulcer healing rate after 4 weeks was significantly higher in patients treated with nocloprost than in those treated with ranitidine (63% versus 39%, respectively). At initial examination the EGF content in the gastric mucosa obtained from the ulcer edge was significantly higher than that in the intact mucosa. There was a significant increase in the EGF content in both the ulcer margin and the intact mucosa in subjects treated with nocloprost but not in patients under treatment with ranitidine. Similarly, patients treated with nocloprost had significantly higher EGF output in saliva and higher EGF concentration in plasma throughout the anti- ulcer therapy. CONCLUSION:
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Authors | J W Konturek, K Hengst, S J Konturek, W Domschke |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 32
Issue 10
Pg. 980-4
(Oct 1997)
ISSN: 0036-5521 [Print] England |
PMID | 9361169
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Ulcer Agents
- Prostaglandins F, Synthetic
- Epidermal Growth Factor
- nocloprost
- Ranitidine
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Topics |
- Adult
- Anti-Ulcer Agents
(therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Epidermal Growth Factor
(metabolism)
- Female
- Gastric Mucosa
(metabolism)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Prostaglandins F, Synthetic
(therapeutic use)
- Ranitidine
(therapeutic use)
- Stomach Ulcer
(drug therapy, physiopathology)
- Time Factors
- Wound Healing
(drug effects)
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