Effect of glucose-cysteine adduct on cysteine desulfuration in guinea pig tissues.

Abstract

Effect of intraperitoneal administration (12 mmol/kg of body weight) of glucose-cysteine adduct 2-(D-gluco-pentahydroxypentyl)-thiazolidine-4-carboxylate, (glc-cys) on the rhodanese, gamma-cystathionase and 3-mercaptopyruvate sulfurtransferase (MPST) activity levels in guinea pig tissues was studied. The rhodanese activity value in liver increased by 41%, 3-mercaptopyruvate sulfurtransferase by 24%, and gamma-cystathionase by 12% after three successive days of the administration. In the kidney, on the contrary, glc-cys administration resulted in about 18% decrease in the gamma-cystathionase activity value, whereas no changes in MPST and rhodanese activity values were observed. In the case of the brain, rhodanese and gamma-cystathionase did not change their activity but the activity of MPST decreased by 21%. MPST level did not change substantially in whole blood after glc-cys treatment. The results seem to indicate that in guinea pig liver but not in kidney and brain, glc-cys has a potential to activate the desulfuration pathway of L-cysteine metabolism.

• Authors: M Wróbel, T Ubuka, W B Yao, T Abe
• Journal: Physiological chemistry and physics and medical NMR (Physiol Chem Phys Med NMR) Vol. 29 Issue 1 Pg. 11-4 ( 1997) ISSN: 0748-6642 [Print] United States
• PMID: 9353953 (Publication Type: Journal Article)

Chemical References

• glucose-cysteine
• Sulfur
• Sulfurtransferases
• Thiosulfate Sulfurtransferase
• 3-mercaptopyruvate sulphurtransferase
• Cystathionine gamma-Lyase
• Glucose
• Cysteine

Topics

• Animals
• Cystathionine gamma-Lyase (blood, metabolism)
• Cysteine (analogs & derivatives, metabolism, toxicity)
• Glucose (analogs & derivatives, toxicity)
• Guinea Pigs
• Male
• Sulfur (metabolism)
• Sulfurtransferases (blood, metabolism)
• Thiosulfate Sulfurtransferase (blood, metabolism)
• Tissue Distribution