Autoimmune progesterone dermatitis: effective prophylactic treatment with danazol.

Abstract

BACKGROUND:

Autoimmune progesterone dermatitis is a rare condition appearing during the perimenstrual period or following progesterone treatment. Various treatment modalities have been suggested, but most have proved to be ineffective.

METHODS:

We used the anabolic androgen danazol as a preventive treatment for recurrent episodes of autoimmune progesterone dermatitis in two young women. The treatment regimen consisted of 200 mg danazol twice daily, starting 1-2 days before the expected date of each menses and continuing for 3 days thereafter.

RESULTS:

This treatment regimen proved to be highly effective in preventing the eruptions in these two patients.

CONCLUSIONS:

Patients with autoimmune progesterone dermatitis may benefit from prophylactic treatment with danazol.

• Authors: E Shahar, R Bergman, S Pollack
• Journal: International journal of dermatology (Int J Dermatol) Vol. 36 Issue 9 Pg. 708-11 (Sep 1997) ISSN: 0011-9059 [Print] England
• PMID: 9352418 (Publication Type: Case Reports, Journal Article)

Chemical References

• Estrogen Antagonists
• Progesterone
• Danazol

Topics

• Adult
• Autoimmune Diseases (chemically induced, immunology, pathology, prevention & control)
• Biopsy, Needle
• Danazol (therapeutic use)
• Dermatitis (immunology, pathology, prevention & control)
• Drug Eruptions (pathology, prevention & control)
• Estrogen Antagonists (therapeutic use)
• Female
• Follow-Up Studies
• Humans
• Menstrual Cycle (immunology)
• Progesterone (adverse effects, immunology)