Propranolol-induced seizures in mice: the role of noradrenaline.

Abstract

The effects of some noradrenergic agents, phenobarbitone, diazepam and phenytoin on seizures produced by propranolol were investigated in mice. Isoprenaline and DL-threo-3,4-dihydroxyphenylserine (DOPS) effectively antagonized the seizures elicited by propranolol. Pargyline and imipramine significantly attenuated propranolol-induced seizures and also significantly potentiated the protecting effect of DOPS against the seizures. alpha-Methyl-p-tyrosine, disulfiram and reserpine significantly potentiated propranolol-elicited seizures. However, DOPS significantly antagonized the seizure-potentiating effects of alpha-methyl-p-tyrosine, disulfiram and reserpine. Phenylephrine, clonidine, prazosin, idazoxan, phenobarbitone, diazepam and phenytoin did not significantly alter propranolol-induced seizures. These results suggest that propranolol-induced seizures in mice may involve a noradrenergic mechanism mediated via central beta-adrenoceptors.

• Authors: G J Amabeoku, J A Syce
• Journal: Cellular and molecular life sciences : CMLS (Cell Mol Life Sci) Vol. 53 Issue 8 Pg. 646-51 (Aug 1997) ISSN: 1420-682X [Print] Switzerland
• PMID: 9351467 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic Uptake Inhibitors
• Adrenergic alpha-Agonists
• Adrenergic beta-Agonists
• alpha-Methyltyrosine
• Reserpine
• Pargyline
• Propranolol
• Droxidopa
• Isoproterenol
• Imipramine
• Disulfiram
• Norepinephrine

Topics

• Adrenergic Uptake Inhibitors (pharmacology)
• Adrenergic alpha-Agonists (pharmacology)
• Adrenergic beta-Agonists (pharmacology)
• Animals
• Disulfiram (pharmacology)
• Droxidopa (pharmacology)
• Drug Synergism
• Female
• Imipramine (pharmacology)
• Isoproterenol (pharmacology)
• Male
• Mice
• Norepinephrine (physiology)
• Pargyline (pharmacology)
• Propranolol
• Reserpine (pharmacology)
• Seizures (chemically induced)
• alpha-Methyltyrosine (pharmacology)