Quantification of cat's articular afferents containing calcitonin gene-related peptide or substance P innervating normal and acutely inflamed knee joints.

Abstract

In cats with an acute (32 h) unilateral knee joint inflammation the proportion of calcitonin gene-related peptide-(CGRP) and substance P-(SP) immunoreactive articular afferents, retrogradely labelled by Fast Blue (FB), were determined using immunohistochemistry. The proportion of neurons containing CGRP was significantly higher on the inflamed side (52%) than on the contralateral side (39%) and in controls (42%). However, the proportion of SP-immunoreactive articular perikarya on the inflamed side (26%) did not differ from the contralateral side (24%) and the control cats (22%). These data indicate that acute inflammation induces the synthesis of CGRP but not of SP in joint afferents.

• Authors: U Hanesch, B Heppelmann, R F Schmidt
• Journal: Neuroscience letters (Neurosci Lett) Vol. 233 Issue 2-3 Pg. 105-8 (Sep 19 1997) ISSN: 0304-3940 [Print] Ireland
• PMID: 9350843 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Substance P
• Calcitonin Gene-Related Peptide

Topics

• Acute Disease
• Afferent Pathways (chemistry, drug effects)
• Animals
• Arthritis (chemically induced, pathology)
• Calcitonin Gene-Related Peptide (analysis)
• Case-Control Studies
• Cats
• Female
• Knee Joint (innervation)
• Male
• Reference Values
• Substance P (analysis)