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[Treatment of diabetes mellitus with long-acting biguanides].

Abstract
The paper discusses of the results of treatment with preparations of phenylethylbiguanide (dibotin, meltrol, dipar, dibophen-retard), of butylbiguanide (silubin-retard, buforming-retard) and of dimethyl-biguanide (glucophage-retard). All these preparations were of prolonged action. The treatment was carried out in 242 patients. The saccharolytic action of the active agent contained in one tablet of each type of biguanide was approximately the same. Biguanides of prolonged action were highly effective in obese patients with diabetes mellitus of moderate severity. The best results were obtained in complex treatment with biguanides of prolonged action together with sulfonylurea preparations of the second generation. There were noted almost no toxic reactions from the use of biguanides up to 2 tablets a day.
AuthorsV R Kliachko, A A Perelygina, A G Mazovetskiĭ, L S Slavina
JournalProblemy endokrinologii (Probl Endokrinol (Mosk)) 1976 May-Jun Vol. 22 Issue 3 Pg. 22-6 ISSN: 0375-9660 [Print] Russia (Federation)
Vernacular TitleOpyt terapii sakharnogo diabeta biguanidami prodlennogo deĭstviia
PMID935083 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Biguanides
  • Sulfonylurea Compounds
Topics
  • Adult
  • Aged
  • Biguanides (administration & dosage, adverse effects, therapeutic use)
  • Diabetes Mellitus (drug therapy)
  • Drug Therapy, Combination
  • Dyspepsia (chemically induced)
  • Humans
  • Middle Aged
  • Obesity
  • Sulfonylurea Compounds (administration & dosage)

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