p53 mutations implicate sunlight in post-transplant skin cancer irrespective of human papillomavirus status.

Abstract

Mutations in p53 were detected in 11/23 (48%) of non melanoma skin cancers in renal allograft recipients and in 5/8 (63%) of sporadic tumours from immune competent patients. 9/12 (75%) of mutations in transplant patients and all 5 mutations in non transplant tumours were consistent with damage caused by ultraviolet (u.v.) irradiation. DNA sequences, predominantly of the epidermodysplasia verruciformis (EV) subgroup, were detected in 9/23 (39%) of transplant tumours and in 2/8 (25%) of eight non-transplant tumours. There was no relationship between HPV status and p53 mutation, HPV DNA being present in 5/16 (31%) of tumours with p53 mutation and 6/15 (40%) of tumours lacking p53 mutation. These data are consistent with an important role for sunlight in the development of post-transplant skin cancer, and with limited functional data suggesting that E6 proteins of the cutaneous and EV-related papillomaviruses do not target p53 for ubiquitin-mediated degradation.

• Authors: J M McGregor, R J Berkhout, M Rozycka, J ter Schegget, J N Bouwes Bavinck, L Brooks, T Crook
• Journal: Oncogene (Oncogene) Vol. 15 Issue 14 Pg. 1737-40 (Oct 02 1997) ISSN: 0950-9232 [Print] England
• PMID: 9349508 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• DNA Damage (radiation effects)
• Genes, p53
• Humans
• Kidney Transplantation
• Mutation
• Neoplasms, Radiation-Induced (genetics)
• Papillomaviridae (pathogenicity)
• Polymorphism, Single-Stranded Conformational
• Skin Neoplasms (etiology, genetics)
• Sunlight