Phase II clinical trial of carboplatin in canine transitional cell carcinoma of the urinary bladder.

Abstract

Fourteen dogs with histologically-confirmed transitional cell carcinoma (TCC) of the urinary bladder were treated with 300 mg/m2 carboplatin every 3 weeks. Response to therapy was assessed with abdominal radiography, double contrast cystography, urinary bladder ultrasonography and thoracic radiography before therapy and at 6-week intervals during therapy. Dogs were monitored for hematologic toxicity with a CBC and platelet count performed immediately before and 10 to 14 days after carboplatin treatment. Tumor responses included progressive disease in 11 dogs and stable disease in 1 dog. Two dogs were euthanized due to carboplatin toxicity before assessment of tumor response. Toxicity included thrombocytopenia with or without neutropenia in 7 dogs and gastrointestinal toxicity in 6 dogs. Carboplatin therapy was not beneficial in the treatment of TCC in the 14 dogs in this study.

• Authors: R Chun, D W Knapp, W R Widmer, D B DeNicola, N W Glickman, T Kuczek, A Degortari, C M Han
• Journal: Journal of veterinary internal medicine (J Vet Intern Med) 1997 Sep-Oct Vol. 11 Issue 5 Pg. 279-83 ISSN: 0891-6640 [Print] United States
• PMID: 9348494 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Carboplatin

Topics

• Animals
• Antineoplastic Agents (adverse effects, pharmacokinetics, therapeutic use)
• Carboplatin (adverse effects, pharmacokinetics, therapeutic use)
• Carcinoma, Transitional Cell (drug therapy, pathology, veterinary)
• Dog Diseases (diagnostic imaging, drug therapy, pathology)
• Dogs
• Dose-Response Relationship, Drug
• Female
• Incidence
• Male
• Neutropenia (chemically induced, epidemiology, veterinary)
• Radiography, Abdominal (methods, veterinary)
• Radiography, Thoracic (veterinary)
• Thrombocytopenia (chemically induced, epidemiology, veterinary)
• Ultrasonography
• Urinary Bladder (diagnostic imaging, drug effects, pathology)
• Urinary Bladder Neoplasms (drug therapy, pathology, veterinary)