Abstract | OBJECTIVE: PATIENTS: METHODS: RESULTS: During acute malaria infection, the systemic clearance of quinine, antipyrine and ICG and the biotransformation of quinine to 3-hydroxyquinine were all reduced significantly when compared with values during convalescence. Iothalamate clearance was not affected significantly and did not correlate with the clearance of any of the other compounds. The clearance of total and free quinine correlated significantly with antipyrine clearance (rs = 0.70, P = 0.005 and rs = 0.67, P = 0.013, respectively), but not with ICG clearance (rs = 0.39 and 0.43 respectively, P > 0.15). In a multiple regression model, antipyrine clearance and plasma protein binding accounted for 71% of the variance in total quinine clearance in acute malaria. The pharmacokinetic properties of dihydroquinine were generally similar to those of quinine, although dihydroquinine clearance was less affected by acute malaria. The mean ratio of quinine to 3-hydroxyquinine area under the plasma concentration-time curve (AUC) values in acute malaria was 12.03 compared with 6.92 during convalescence P = 0.01. The mean plasma protein binding of 3-hydroxyquinine was 46%, which was significantly lower than that of quinine (90.5%) or dihydroquinine (90.5%). CONCLUSION:
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Authors | S Pukrittayakamee, S Looareesuwan, D Keeratithakul, T M Davis, P Teja-Isavadharm, B Nagachinta, A Weber, A L Smith, D Kyle, N J White |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 52
Issue 6
Pg. 487-93
( 1997)
ISSN: 0031-6970 [Print] Germany |
PMID | 9342585
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimalarials
- Iothalamic Acid
- Quinine
- Indocyanine Green
- Antipyrine
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Topics |
- Adolescent
- Adult
- Animals
- Antimalarials
(pharmacokinetics)
- Antipyrine
(pharmacokinetics)
- Area Under Curve
- Biological Availability
- Female
- Half-Life
- Humans
- Indocyanine Green
(pharmacokinetics)
- Iothalamic Acid
(pharmacokinetics)
- Malaria, Falciparum
(metabolism)
- Male
- Metabolic Clearance Rate
- Middle Aged
- Plasmodium falciparum
- Quinine
(pharmacokinetics)
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