Abstract | OBJECTIVE: DESIGN: SETTING: The otolaryngology department of a university teaching hospital. INTERVENTION: All ears were treated topically for 3 weeks. MAIN OUTCOME MEASURES: Each patient received a small, numbered bottle and was instructed to instill 5 drops 3 times daily for 3 weeks. The final clinical and bacteriologic assessment was made after 3 weeks. RESULTS: The organism most commonly isolated from the ear discharge was Pseudomonas aeruginosa. Its sensitivity to ciprofloxacin and tobramycin was 94.2% and 70.6%, respectively. The clinical response was 78.9%, 72.2%, and 41.2% in the ciprofloxacin, tobramycin, and placebo groups, respectively. The bacteriologic response rate was 66.7% for the ciprofloxacin and tobramycin groups and 20% for the placebo group. Treatment with ciprofloxacin ear drops seemed to be as effective as treatment with tobramycin. CONCLUSION:
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Authors | M Fradis, A Brodsky, J Ben-David, I Srugo, J Larboni, L Podoshin |
Journal | Archives of otolaryngology--head & neck surgery
(Arch Otolaryngol Head Neck Surg)
Vol. 123
Issue 10
Pg. 1057-60
(Oct 1997)
ISSN: 0886-4470 [Print] United States |
PMID | 9339980
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Ciprofloxacin
- Tobramycin
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Topics |
- Administration, Topical
- Adult
- Aged
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Anti-Infective Agents
(administration & dosage, therapeutic use)
- Chronic Disease
- Ciprofloxacin
(administration & dosage, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Male
- Microbial Sensitivity Tests
- Middle Aged
- Otitis Media
(drug therapy, microbiology)
- Prospective Studies
- Pseudomonas Infections
(drug therapy)
- Pseudomonas aeruginosa
(drug effects)
- Tobramycin
(administration & dosage, therapeutic use)
- Treatment Outcome
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