Painful oral ulcers with hydroxyurea therapy.

Abstract

Five patients treated with hydroxyurea for various haematological malignancies developed multiple painful oral ulcers. Their neutrophil counts were either normal or elevated. The ulcers disappeared with cessation of hydroxyurea. Oral ulcers recurred when hydroxyurea was resumed in one of the patients. As the patients were unable to tolerate this painful side effect, hydroxyurea had to be discontinued. Appearance of painful oral ulceration seems to be independent of dosing rate or total cumulative dose of hydroxyurea.

• Authors: M R Norhaya, S K Cheong, O Ainoon, N H Hamidah
• Journal: Singapore medical journal (Singapore Med J) Vol. 38 Issue 7 Pg. 283-4 (Jul 1997) ISSN: 0037-5675 [Print] India
• PMID: 9339092 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Hydroxyurea

Topics

• Adolescent
• Adult
• Aged
• Antineoplastic Agents (adverse effects, therapeutic use)
• Dose-Response Relationship, Drug
• Female
• Hematologic Diseases (drug therapy)
• Humans
• Hydroxyurea (adverse effects, therapeutic use)
• Male
• Middle Aged
• Oral Ulcer (chemically induced)