Therapeutic effects of omoconazole nitrate on experimental tinea pedis, an intractable dermatophytosis, in guinea-pigs.

Abstract

The therapeutic efficacy of omoconazole nitrate was investigated in an experimental tinea pedis model produced by topical inoculation with Trichophyton mentagrophytes in guinea-pigs, which is pathologically similar to naturally infected tinea pedis in humans. Treatment with omoconazole nitrate cream was started on week 2 postinfection and continued for 3 or 4 weeks. Once-a-day application of 1% omoconazole nitrate to the site of infection exhibited an excellent therapeutic efficacy, and was superior to 1% bifonazole cream in culture result. This result suggests that omoconazole nitrate has a potential usefulness for the treatment of tinea pedis in humans.

• Authors: T Itoyama, K Uchida, H Yamaguchi, S Fujita
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 40 Issue 3 Pg. 441-4 (Sep 1997) ISSN: 0305-7453 [Print] England
• PMID: 9338501 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Imidazoles
• omoconazole
• bifonazole

Topics

• Animals
• Antifungal Agents (therapeutic use)
• Female
• Guinea Pigs
• Imidazoles (therapeutic use)
• Tinea Pedis (drug therapy, microbiology)