Abstract |
Respiratory and otitis isolates of 807 Streptococcus pneumoniae, 816 Haemophilus influenzae and 446 Moraxella catarrhalis were collected from 21 clinical microbiology laboratories for antimicrobial susceptibility testing in 1995. After a period of relative stability in 1981 and 1987-1990, beta-lactamase production increased in H. influenzae. Among middle ear isolates from children under 6 years, beta-lactamase production increased from 8% to 24% in H. influenzae and from 81% to 96% in M. catarrhalis since the survey in 1987-1990. 1.2% of S. pneumoniae were penicillin-resistant and 4.2% intermediately resistant; 5 years earlier among otitis isolates of children only 1.7% intermediate resistance was found. Ampicillin resistance was seen among 1.9% of non- beta-lactamase-producing strains of H. influenzae. Resistance to trimethoprim- sulphamethoxazole occurred in 9.4% of S. pneumoniae, 7.4% of H. influenzae and 0.7% of M. catarrhalis. Frequencies of azithromycin resistance were 3.0% in S. pneumoniae and 1.6% in H. influenzae, and those of tetracycline resistance were 6.7% in S. pneumoniae and 1.2% in H. influenzae.
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Authors | R Manninen, P Huovinen, A Nissinen |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 40
Issue 3
Pg. 387-92
(Sep 1997)
ISSN: 0305-7453 [Print] England |
PMID | 9338492
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Lactams
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Topics |
- Adolescent
- Anti-Bacterial Agents
(pharmacology)
- Cephalosporin Resistance
- Child, Preschool
- Drug Resistance, Microbial
- Finland
- Haemophilus influenzae
(drug effects, enzymology)
- Humans
- In Vitro Techniques
- Infant, Newborn
- Lactams
- Microbial Sensitivity Tests
- Moraxella catarrhalis
(drug effects, enzymology)
- Otitis
(microbiology)
- Penicillin Resistance
- Respiratory Tract Infections
(microbiology)
- Streptococcus pneumoniae
(drug effects, enzymology)
- Trimethoprim Resistance
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