Activity and tissue localization of cathepsin G in non small cell lung cancer.

Abstract

Activity and tissue localization of cathepsin G were examined in tumors deriving from 73 patients with non small cell lung cancer. Activity of cathepsin G was highest in adenocarcinoma, lower in planoepitheliale cancer, the lowest in macrocellular cancer. In all histological types of tumors cathepsin G activity in supernatants was lower than in sediments. The enzyme immunohistochemically was localized in neutrophils. There is evident correlation between neutrophil numbers and cathepsin G activity in examined cancer types. Result of our examinations indicate a relationship between cathepsin G activity, grade of tumor differentiation and particular clinical stages of disease.

• Authors: T Maksimowicz, E Chyczewska, L Chyczewski, J Nikliński, H Ostrowska, J Szyszko, M Furman
• Journal: Roczniki Akademii Medycznej w Bialymstoku (1995) (Rocz Akad Med Bialymst) Vol. 42 Suppl 1 Pg. 199-216 ( 1997) Poland
• PMID: 9337538 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Neoplasm Proteins
• Cathepsins
• Serine Endopeptidases
• CTSG protein, human
• Cathepsin G

Topics

• Adenocarcinoma (enzymology, pathology, ultrastructure)
• Adult
• Aged
• Carcinoma, Large Cell (enzymology, pathology, ultrastructure)
• Carcinoma, Non-Small-Cell Lung (enzymology, pathology, ultrastructure)
• Carcinoma, Squamous Cell (enzymology, pathology, ultrastructure)
• Cathepsin G
• Cathepsins (analysis)
• Cell Differentiation
• Cell Fractionation
• Female
• Humans
• Lung (enzymology)
• Lung Neoplasms (enzymology, pathology, ultrastructure)
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Proteins (analysis)
• Neoplasm Staging
• Neutrophils (enzymology)
• Serine Endopeptidases
• Solubility