A computer program (Q-test) was used to evaluate the combined toxic effects of
nerve agent GF and its combined form with
sarin (GB/GF) in mice. Efficacy of Jielin Injection, the 2-PAM-containing
antidote used successfully in China for the treatment of
organophosphate pesticide poisoning, was also evaluated and compared with
HI-6 against single and combined
poisonings. The two agents were basically additive in toxicity when combined. However, toxic signs (convulsions) appeared later in combined
poisoning than after exposure to each agent alone. The protective ratio of Jielin Injection against GF
poisoning was low but significantly higher when against
poisoning by GB or combined agent. When
HI-6 was substituted for
2-PAM, the
antidote was more effective against
poisoning by both single and combined agents. Results of in vitro reactivation of GF-inhibited human erythrocyte
acetylcholinesterase by these
oximes agreed with the in vivo antidotal efficacy.