[Immunohistochemical study of oncogene c-erbb-2 expression and extracellular matrix proteins in breast cancer (various mechanisms of invasion)].

Abstract

55 breast carcinomas and 9 its benign conditions were studied immunohistochemically. Oncoprotein c-erbB-2 was found in 22% carcinomas and in 33-37% comedo-carcinomas. Coincidence of predominant expression of oncoprotein c-erbB-2 and tenascin was observed. Maximal damage of the basal membrane in the intraductal carcinoma detected by the disturbance of type IV collagen staining was observed in cases of the highest expression of oncoprotein c-erbB-2 and tenascin.

• Authors: K M Pozharisskiĭi, A Sh Kyshtoobaeva, E A Turkevich
• Journal: Arkhiv patologii (Arkh Patol) 1997 Jul-Aug Vol. 59 Issue 4 Pg. 19-25 ISSN: 0004-1955 [Print] Russia (Federation)
• Vernacular Title: Immunogistokhimicheskoe izuchenie ékspressii onkogena c-erbb-2 i belkov vnekletochnogo matriksa v rake molochnoĭ zhelezy (k voprosu o nekotorykh mekhanizmakh invazii)
• PMID: 9334150 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Extracellular Matrix Proteins
• Neoplasm Proteins

Topics

• Aged
• Aged, 80 and over
• Breast Neoplasms (chemistry, genetics, pathology)
• Extracellular Matrix Proteins (analysis)
• Female
• Gene Expression Regulation, Neoplastic (physiology)
• Genes, erbB-2
• Humans
• Immunohistochemistry
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Proteins (analysis)