[Balneophotochemotherapy with 8-methoxypsoralen in lichen sclerosis et atrophicus].

Abstract

A 66-year-old woman with longstanding lichen sclerosus et atrophicus improved strikingly with PUVA bath photochemotherapy over a period of 6 weeks. The cumulative UVA dose was 31.7 J/cm2; the single UVA dose ranged from 0.3 to 2.3 J/cm2. After 16 treatment sessions, the sclerotic lesions had softened greatly, while after 24 treatments, the skin lesions were almost completely cleared and pruritus was diminished. Histopathological analysis of biopsy specimens from previously affected sites as well as 20 MHz ultrasound examinations showed almost no residual sclerosis. Although long-term results are not yet available, PUVA bath photochemotherapy seems to be a promising and effective new treatment modality without systemic side effects for patients with disseminated lichen sclerosus et atrophicus.

• Authors: G von Kobyletzki, M Freitag, K Hoffmann, P Altmeyer, M Kerscher
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 48 Issue 7 Pg. 488-91 (Jul 1997) ISSN: 0017-8470 [Print] Germany
• Vernacular Title: Balneophotochemotherapie mit 8-Methoxypsoralen bei Lichen sclerosus et atrophicus.
• PMID: 9333629 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Aged
• Balneology
• Biopsy
• Combined Modality Therapy
• Female
• Humans
• Lichen Sclerosus et Atrophicus (pathology, therapy)
• PUVA Therapy
• Skin (pathology)
• Treatment Outcome