[The blood concentration of flurenizid in patients with destructive pulmonary tuberculosis].

Abstract

Some pharmacokinetic features of new capsulated and tableted antituberculous drug flurenizidum were studied microbiologically in 50 adult patients with advanced pulmonary tuberculosis. Flurenizidum in vitro shows high mycobacteriostatic activity: it suppresses growth of Mycobacteria tuberculosis H37Rv strain in concentration of 0.05 mkg/ml. Single doze of flurenizidum--0.3 and 0.6 g--provided mycobacteriostatic blood concentration for 6 and 12 hours respectively. Maximum concentrations of the drug (0.46 +/- 0.07) mkg/ml and (1.02 +/- 0.14) mkg/ml respectively were observed in 3 hours after administration.

• Authors: V O Panasiuk, V I Mykhal'chuk
• Journal: Likars'ka sprava (Lik Sprava) 1997 Mar-Apr Issue 2 Pg. 37-9 ISSN: 1019-5297 [Print] Ukraine
• Vernacular Title: Kontsentratsiia flurenizydu v krovi khvorykh na destruktyvnyĭ tuberkul'oz lehen'.
• PMID: 9333479 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antitubercular Agents
• Capsules
• Heterocyclic Compounds
• Tablets
• flurenizid

Topics

• Adult
• Antitubercular Agents (administration & dosage, blood)
• Capsules
• Chronic Disease
• Dose-Response Relationship, Drug
• Heterocyclic Compounds (administration & dosage, blood)
• Humans
• Microbial Sensitivity Tests (methods)
• Mycobacterium tuberculosis (drug effects)
• Tablets
• Time Factors
• Tuberculosis, Pulmonary (blood, drug therapy)