Abstract | BACKGROUND: SUBJECTS AND METHODS: Thirty-four postmenopausal patients previously treated with tamoxifen in the adjuvant setting and/ or for advanced disease were treated with vorozole, 2.5 mg once daily. Patients were monitored with respect to treatment efficacy and safety. Hormonal evaluations were performed at baseline and during the course of treatment in order to evaluate the pharmacodynamic efficacy and safety of vorozole. RESULTS: According to UICC criteria, there were seven responders, one complete and six partial, for an overall response rate of 21% (95% confidence interval (CI) 9%-38%). The median duration of response was 9.6 months (95% CI 4.6-0), the median time to progression for the entire group was 4.7 months (95% CI 2.9-6.6) and the median survival time was 29.7 months (95% CI 19.1-0). Tolerability was excellent to good in 97% of the patients. Oestradiol and oestrone levels were suppressed to the limit of detection of the assays used. No effect was observed on the other endocrine parameters. CONCLUSIONS:
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Authors | F Boccardo, D Amoroso, S Iacobelli, L Irtelli, A Farris, G Mustacchi, M Mesiti, F Brema, P Pacini, E Cortesi, P Nardini, G Guida, C Langenaeken |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 8
Issue 8
Pg. 745-50
(Aug 1997)
ISSN: 0923-7534 [Print] England |
PMID | 9332681
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study)
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Chemical References |
- Antineoplastic Agents
- Aromatase Inhibitors
- Enzyme Inhibitors
- Triazoles
- vorozole
- Estrone
- Estradiol
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Topics |
- Aged
- Antineoplastic Agents
(therapeutic use)
- Aromatase Inhibitors
- Breast Neoplasms
(drug therapy)
- Enzyme Inhibitors
(therapeutic use)
- Estradiol
(blood)
- Estrone
(blood)
- Female
- Humans
- Middle Aged
- Postmenopause
- Triazoles
(adverse effects, blood, therapeutic use)
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