| Abstract | Sequence variability of the outer surface protein (Osp) A among Borrelia burgdorferi sl species suggests that a monovalent OspA vaccine may not protect against the various Borrelia present in Eurasia. Here, we confirmed that a monovalent recombinant OspA (rOspA) vaccine does not protect mice against Ixodes ricinus mediated infection with B. burgdorferi ss, Borrelia garinii and Borrelia afzelii. However, when mice were vaccinated with a cocktail of various rOspA from these three species, they were protected, and all challenge ticks that fed on them were cleared of their spirochetes. These results showed that a multiple OspA antigens vaccine, compatible with human use, was very efficient at protecting mice against B. burgdorferi ss, B. garinii, and B. afzelii. |
| Authors | L Gern, C M Hu, P Voet, P Hauser, Y Lobet
(Affiliation: Institut de Zoologie, University of Neuchâtel, Switzerland. lise.gern at zool.unine.ch)
|
| Journal | Vaccine
(Vaccine)
Vol. 15
Issue 14
Pg. 1551-7
(Oct 1997)
ISSN: 0264-410X ENGLAND |
| PMID | 9330467
(Publication Type: Journal Article)
|
| Chemical References |
- Antibodies, Bacterial
- Antigens, Surface
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Lipoproteins
- OspA protein
|
| Topics |
- Animals
- Antibodies, Bacterial
(blood)
- Antigens, Surface
(immunology)
- Bacterial Outer Membrane Proteins
(immunology)
- Bacterial Vaccines
(immunology)
- Blotting, Western
- Female
- Immunization
- Insect Vectors
(microbiology)
- Ixodes
(microbiology)
- Lipoproteins
- Lyme Disease
(diagnosis, prevention & control)
- Mice
- Mice, Inbred BALB C
|
