HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Experimental models of gene-environment interaction for cancer chemoprevention studies.

Abstract
The recent development of mouse strains with cancer-related genes overexpressed or inactivated has provided investigators with new models for testing chemoprevention strategies to offset specific genetic susceptibilities to cancer. This review focuses on the three genetically altered mouse models that have been the most widely used in chemoprevention studies: Min mice, which carry a mutation in the adenomatous polyposis coli (APC) gene; APC-knockout mice; and p53-knockout mice. Studies with the Min and APC-knockout mice provide the strongest evidence to date that the enzyme cyclooxygenase-2 plays a major role in colon carcinogenesis, and that nonsteroidal anti-inflammatory drugs that target cyclooxygenase-2 have great potential as colon cancer chemopreventive agents. In addition, chemoprevention studies in mice deficient of the p53 tumor-suppressor gene, the most commonly altered gene in human cancer, suggest that the increased susceptibility to cancer resulting from the loss of p53 function may be offset by preventive approaches. Other recently developed transgenic and knockout models of potential interest for chemoprevention studies will also be discussed.
AuthorsS D Hursting
JournalCurrent opinion in oncology (Curr Opin Oncol) Vol. 9 Issue 5 Pg. 487-91 (Sep 1997) ISSN: 1040-8746 [Print] UNITED STATES
PMID9327228 (Publication Type: Journal Article, Review)
Topics
  • Animals
  • Chemoprevention
  • Environment
  • Genes, p53
  • Humans
  • Intestinal Neoplasms (prevention & control)
  • Mice
  • Mice, Knockout
  • Neoplasms (etiology, genetics, prevention & control)
  • Neoplasms, Experimental (etiology, genetics, prevention & control)
  • Oncogenes

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: