Systemic administration of ACTH or vasopressin reverses the amnestic effect of posttraining beta-endorphin or electroconvulsive shock but not that of intrahippocampal infusion of protein kinase inhibitors.

Abstract

Retrograde amnesia was induced in rats trained in step-down inhibitory avoidance by four different treatments: an ip injection of beta-endorphin (1.0 microgram kg), an electroconvulsive shock (ECS), an intrahippocampal infusion of the calcium/calmodulin protein kinase II inhibitor, KN62 (0.08 microgram/side), given 0 h after training, or an intrahippocampal infusion of the protein kinase A inhibitor, KT5720 (0.5 microgram/side), given 3 h after training. Pretest ip injections of ACTH (0.2 microgram/kg) or vasopressin (10.0 micrograms/kg), but not saline, reversed the amnesia caused by beta-endorphin and ECS but not that caused by the enzyme inhibitors. This suggests that the amnesia produced by intrahippocampal KN62 and KT5720 administration is stronger than that caused by ECS and beta-endorphin, possibly because the former interfere directly with specific steps of the core biochemical chain of events that underlies memory consolidation.

• Authors: L A Izquierdo, N Schröder, P Ardenghi, J Quevedo, C A Netto, J H Medina, I Izquierdo
• Journal: Neurobiology of learning and memory (Neurobiol Learn Mem) Vol. 68 Issue 2 Pg. 197-202 (Sep 1997) ISSN: 1074-7427 [Print] United States
• PMID: 9322261 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbazoles
• Enzyme Inhibitors
• Indoles
• Pyrroles
• Cosyntropin
• Lypressin
• KT 5720
• beta-Endorphin
• KN 62
• 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
• Calcium-Calmodulin-Dependent Protein Kinases

Topics

• 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine (analogs & derivatives, pharmacology)
• Animals
• Arousal (drug effects, physiology)
• Calcium-Calmodulin-Dependent Protein Kinases (antagonists & inhibitors, physiology)
• Carbazoles
• Cosyntropin (pharmacology)
• Dose-Response Relationship, Drug
• Enzyme Inhibitors (pharmacology)
• Fear (drug effects, physiology)
• Hippocampus (drug effects, physiology)
• Indoles (pharmacology)
• Injections, Intraperitoneal
• Lypressin (pharmacology)
• Male
• Mental Recall (drug effects)
• Neural Pathways (drug effects, physiology)
• Pyrroles (pharmacology)
• Rats
• Rats, Wistar
• Retention, Psychology (drug effects, physiology)
• beta-Endorphin (antagonists & inhibitors, pharmacology)