| Abstract | OBJECTIVE: The purpose of the study was to examine the relationship between gastric emptying and the efficacy of an alpha-glucosidase inhibitor in NIDDM patients. RESEARCH DESIGN AND METHODS: Sixteen NIDDM patients (4 patients treated with diet therapy alone and 12 receiving a sulfonylurea) were given 0.6 mg of voglibose daily for 4 weeks. The efficacy of voglibose was assessed by measurement of HbA1c, fasting plasma glucose, and 45- and 120-min postprandial plasma glucose (PPG) and serum insulin concentrations before and after the 4 weeks of voglibose therapy. Gastric emptying was evaluated using the proportional cumulative area under the absorption curve (% AUC) of plasma acetaminophen concentration at 60 min after ingestion of a liquid test meal containing 20 mg/kg of acetaminophen. These measurements were also taken before and after the therapy. RESULTS: The change in the 45-min PPG levels from the fasting state correlated significantly with the % AUC of the plasma acetaminophen concentrations (r = 0.625, P = 0.0096) before the voglibose administrations. The mean 45-min and 2-h PPG levels were reduced significantly after 4 weeks of voglibose (P < 0.05 and P < 0.01, respectively). Two-hour postprandial serum insulin concentrations were also significantly reduced at the end of the treatment period (P < 0.05). The changes in the PPG levels between pre- and posttreatment periods correlated significantly with the % AUC of the plasma acetaminophen concentrations before the treatment period (r = 0.499, P = 0.0490; r = 0.713, P = 0.0019, respectively). There was no significant difference in the plasma acetaminophen concentrations between pre- and posttreatment periods. CONCLUSIONS: The rate of gastric emptying affects the efficacy of voglibose therapy in NIDDM patients. Voglibose did not however alter the rate of gastric emptying. |
| Authors | T Kawagishi, Y Nishizawa, H Taniwaki, S Tanaka, Y Okuno, M Inaba, E Ishimura, M Emoto, H Morii
(Affiliation: Second Department of Internal Medicine, Osaka City University Medical School, Japan.)
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| Journal | Diabetes care
(Diabetes Care)
Vol. 20
Issue 10
Pg. 1529-32
(Oct 1997)
ISSN: 0149-5992 UNITED STATES |
| PMID | 9314629
(Publication Type: Clinical Trial, Journal Article)
|
| Chemical References |
- Blood Glucose
- Enzyme Inhibitors
- Acetaminophen
- Insulin
- Inositol
- voglibose
- alpha-Glucosidases
|
| Topics |
- Acetaminophen
(blood, diagnostic use, pharmacokinetics)
- Blood Glucose
(drug effects, metabolism)
- Diabetes Mellitus, Type 2
(blood, physiopathology)
- Enzyme Inhibitors
(therapeutic use)
- Female
- Gastric Emptying
(drug effects, physiology)
- Humans
- Inositol
(analogs & derivatives, therapeutic use)
- Insulin
(blood)
- Male
- Metabolic Clearance Rate
- Middle Aged
- Postprandial Period
- Regression Analysis
- alpha-Glucosidases
(antagonists & inhibitors)
|
