Abstract | OBJECTIVE: PATIENTS AND METHODS: RESULTS: The rates of excretion of Crosslaps were significantly greater in patients with than in those without bone metastases. Only Crosslaps showed a significant difference between patients with stabilized metastatic disease and those with no bone involvement. Crosslaps had a higher specificity and positive predictive value than had PSA level in patients with bone metastases, and a higher sensitivity than bone ALP. CONCLUSION: These preliminary findings suggest that Crosslaps may be useful as an additional bone marker in patients with prostate cancer and may provide information of the metastatic spread to bone in these patients. Prospective studies with serial measurements of bone markers are currently underway to relate these results to the progression of disease and to evaluate the response to treatment of bone metastases.
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Authors | M Nguyen-Pamart, A Caty, M L Feutrie, C Fournier, P Gosselin, E Mazeman |
Journal | British journal of urology
(Br J Urol)
Vol. 80
Issue 3
Pg. 452-5
(Sep 1997)
ISSN: 0007-1331 [Print] England |
PMID | 9313666
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Alkaline Phosphatase
- Prostate-Specific Antigen
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Topics |
- Aged
- Aged, 80 and over
- Alkaline Phosphatase
(blood)
- Analysis of Variance
- Biomarkers, Tumor
(metabolism)
- Bone Neoplasms
(diagnosis, secondary)
- Humans
- Male
- Middle Aged
- Prostate-Specific Antigen
(analysis)
- Prostatic Hyperplasia
(pathology)
- Prostatic Neoplasms
(metabolism, pathology)
- Sensitivity and Specificity
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