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Comparison of the abilities of human parathyroid hormone(1-31)NH2 and human parathyroid hormone-related protein(1-31)NH2 to stimulate femoral trabecular bone growth in ovariectomized rats.

Abstract
N-terminal fragments of PTH and PTHrP, such as hPTH-(1-34) and hPTHrP-(1-34), are sufficiently similar with respect to amino acid sequence, location of functional domains, and higher order configuration to activate the same PTH/PTHrP receptor and the same two signal enzymes, adenylyl cyclase and phospholipase-Cbeta. Therefore, it was expected that hPTHrP-(1-31)NH2 would stimulate bone growth in ovariectomized rats as strongly as hPTH-(1-31)NH2. Like hPTH-(1-31)NH2, hPTHrP-(1-31)NH2 stimulated adenyly cyclase in ROS 17/2 osteosarcoma cells as strongly as the standard hPTH-(1-34) and like hPTH-(1-31)NH2, triggered a large drop in mean blood pressure when injected intravenously. Unlike hPTH-(1-31)NH2, however, hPTHrP-(1-31)NH2 could not stimulate trabecular growth in the distal femurs of young, sexually mature, ovariectomized rats.
AuthorsJ F Whitfield, P Morley, G E Willick, V Ross, R Langille, S MacLean, J Barbier, R J Isaacs, L Ohannessian-Barry
JournalCalcified tissue international (Calcif Tissue Int) Vol. 61 Issue 4 Pg. 322-6 (Oct 1997) ISSN: 0171-967X [Print] United States
PMID9312203 (Publication Type: Journal Article)
Chemical References
  • PTHLH protein, human
  • Parathyroid Hormone
  • Parathyroid Hormone-Related Protein
  • Peptide Fragments
  • Proteins
  • parathyroid hormone (1-31)amide, human
  • Adenylyl Cyclases
Topics
  • Adenylyl Cyclases (metabolism)
  • Animals
  • Blood Pressure (drug effects)
  • Bone Density (drug effects)
  • Bone Development (drug effects)
  • Bone Neoplasms (enzymology, pathology)
  • Disease Models, Animal
  • Female
  • Femur (drug effects, physiology)
  • Humans
  • Injections, Intravenous
  • Osteoporosis, Postmenopausal (physiopathology)
  • Osteosarcoma (enzymology, pathology)
  • Ovariectomy
  • Parathyroid Hormone (administration & dosage, pharmacology)
  • Parathyroid Hormone-Related Protein
  • Peptide Fragments (administration & dosage, pharmacology)
  • Proteins (administration & dosage, pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Tumor Cells, Cultured

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